Gene name:
Zeb2(Sip1;Zfhx1b;Zfx1b);
Protein name:
Zinc finger E-box-binding homeobox 2;
Alternative:
Zinc finger homeobox protein 1b;Smad-interacting protein 1;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with CBX4 and CTBP1 (By similarity). Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected.
Function:
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MKQPIMADGP | RCKRRKQANP | RRKNVVNYDN | VVDAGSETDE | EDKLHIAEDD |
100:
SLANPLDQDT | SPASMPNHES | SPHMSQGLLP | REEEEEELRE | SVVEHSWHSG |
150:
EILQASVAGP | EEMKEDYDAM | GPEATIQTTI | NNGTVKNANC | TSDFEEYFAK |
200:
RKLEERDGHA | VSIEEYLQRS | DTAIIYPEAP | EELSRLGTPE | ANGQEENDLP |
250:
PGTPDAFAQL | LTCPYCDRGY | KRLTSLKEHI | KYRHEKNEEN | FSCPLCSYTF |
300:
AYRTQLERHM | VTHKPGTDQH | QMLTQGAGNR | KFKCTECGKA | FKYKHHLKEH |
350:
LRIHSGEKPY | ECPNCKKRFS | HSGSYSSHIS | SKKCIGLISV | NGRMRNNIKT |
400:
GSSPNSVSSS | PTNSAITQLR | NKLENGKPLS | MSEQTGLLKI | KTEPLDFNDY |
450:
KVLMATHGFS | GSSPFMNGGL | GATSPLGVHP | SAQSPMQHLG | VGMEAPLLGF |
500:
PTMNSNLSEV | QKVLQIVDNT | VSRQKMDCKT | EDISKLKGYH | MKDPCSQPEE |
550:
QGVTSPNIPP | VGLPVVSHNG | ATKSIIDYTL | EKVNEAKACL | QSLTTDSRRQ |
600:
ISNIKKEKLR | TLIDLVTDDK | MIENHSISTP | FSCQFCKESF | PGPIPLHQHE |
650:
RYLCKMNEEI | KAVLQPHENI | VPNKAGVFVD | NKALLLSSVL | SEKGLTSPIN |
700:
PYKDHMSVLK | AYYAMNMEPN | SDELLKISIA | VGLPQEFVKE | WFEQRKVYQY |
750:
SNSRSPSLER | TSKPLAPNSN | PTTKDSLLPR | SPVKPMDSIT | SPSIAELHNS |
800:
VTSCDPPLRL | TKSSHFTNIK | AVDKLDHSRS | NTPSPLNLSS | TSSKNSHSSS |
850:
YTPNSFSSEE | LQAEPLDLSL | PKQMREPKGI | IATKNKTKAT | SINLDHNSVS |
900:
SSSENSDEPL | NLTFIKKEFS | NSNNLDNKSN | NPVFGMNPFS | AKPLYTPLPP |
950:
QSAFPPATFM | PPVQTSIPGL | RPYPGLDQMS | FLPHMAYTYP | TGAATFADMQ |
1000:
QRRKYQRKQG | FQGDLLDGAQ | DYMSGLDDMT | DSDSCLSRKK | IKKTESGMYA |
1050:
CDLCDKTFQK | SSSLLRHKYE | HTGKRPHQCQ | ICKKAFKHKH | HLIEHSRLHS |
1100:
GEKPYQCDKC | GKRFSHSGSY | SQHMNHRYSY | CKREAEEREA | AEREAREKGH |
1150:
LEPTELLMNR | AYLQSITPQG | YSDSEERESM | PRDGESEKEH | EKEGEEGYGK |
1200:
LRRRDGDEEE | EEEEEESENK | SMDTDPETIR | DEEETGDHSM | DDSSEDGKME |
Vaild Sequence:
Related Databases
Uniprot:
FOR
ELISA Kit for Mouse Zinc finger E-box-binding homeobox 2
ELISA Kit for Mouse Zinc finger E-box-binding homeobox 2
CLIA Kit for Mouse Zinc finger E-box-binding homeobox 2
CLIA Kit for Mouse Zinc finger E-box-binding homeobox 2
Polyclonal Antibody for Mouse Zinc finger E-box-binding homeobox 2
Polyclonal Antibody for Mouse Zinc finger E-box-binding homeobox 2
Monoclonal Antibody for Mouse Zinc finger E-box-binding homeobox 2
Monoclonal Antibody for Mouse Zinc finger E-box-binding homeobox 2
Protein for Mouse Zinc finger E-box-binding homeobox 2
Protein for Mouse Zinc finger E-box-binding homeobox 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
-
1.
"SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes."
Verschueren K.
,
Remacle J.E.
,
Collart C.
,
Kraft H.
,
Baker B.S.
,
Tylzanowski P.
,
Nelles L.
,
Wuytens G.
,
Su M.-T.
,
Bodmer R.
,
Smith J.C.
,
Huylebroeck D.
J. Biol. Chem.274:20489-20498(1999)
[
PubMed]
[
Europe PMC]
[
Abstract]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]
-
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed]
[
Europe PMC]
[
Abstract]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain:
C57BL/6J.
-
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain:
C57BL/6.
tissue:
Brain.